From Jerome’s (347-420 AD) Letter to Paul of Concordia:
Afterwards sin gradually grew more and more virulent, till the ungodliness of the giants brought in its train the shipwreck of the whole world.
Then when the world had been cleansed by the baptism—if I may so call it—of the deluge, human life was contracted to a short span.
Yet even this we have almost altogether wasted, so continually do our iniquities fight against the divine purposes.
The “ungodliness of the giants” seems to be stated due to taking Nephilim to be giants likely based on the Greek Septuagint/LXX.
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